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In this article, Papagiannouli and colleagues show that Dlg, Scrib, Lgl, and clathrin-mediated endocytosis downregulate EGFR signaling levels in the somatic cyst cells of the Drosophila testis. Knockdown of their function in cyst cells results in cell non-autonomous apoptosis of the neighboring germline and increased levels of the EGFR downstream effector MAPK, mediated in part […]