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In this article, Huang and Wang show that heat shock protein 83 (Hsp83/Hsp90), a molecular chaperone, is a novel intrinsic regulator of NSC reactivation. Hsp83 is both necessary and sufficient for NSC reactivation in the presence of nutrition. Both Hsp83 and its co-chaperone Cdc37 physically associate with InR and are required for activation of InR […]