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By directly assessing the repopulating capability of mouse HSPCs in vivo, Morales-Hernández and colleagues describe critical functional differences between two widely used C57BL/6 substrains, including the ability of HSPCs to resolve oxidative stress during HSCT. This finding highlights the critical importance of genetic background when studying HSPCs, especially their metabolism, mitochondrial function, or response to hematopoietic […]